ENTERTAINMENT

The Covid-19 intensive care unit mortality rate has decreased by a THIRD since the pandemic began


The likelihood of surviving the coronavirus after a serious illness has increased significantly since the pandemic began.

Bristol University analysis shows that the proportion of patients who die from Covid-19 in the intensive care unit has decreased by a third since March.

The scientists reviewed more than 20 studies from around the world, involving a total of 10,000 volunteers to come to the conclusion.

They believe the results show that doctors can treat the disease better, which is still poorly understood after jumping from animals to people last year.

Hopefully survival rates will continue to improve after the cheap steroid dexamethasone was the first drug that has been scientifically proven to treat heavy covid.

The anti-inflammatory has been found to reduce the risk of death in ventilated patients by up to 35 percent and in oxygen-containing patients by a fifth.

A small number of scientists believe that the virus is actually getting weaker and that patients are now surviving infections that previously would have killed them.

Viruses are known to change over time because they are subject to random genetic mutations when the infection tries to gain an evolutionary advantage.

If a virus becomes less dangerous to its host – that is, it causes fewer symptoms or less death – it can find that it can live longer and reproduce more.

The family of viruses that cause colds is an example of infections that have weakened over thousands of years. However, there is still no concrete evidence that this happens with Covid-19.

The Covid-19 intensive care unit mortality rate has decreased by a THIRD since the pandemic began.

The new study, published in the journal Anesthesia, examined 24 studies in Europe, Asia and North America, in which 10,150 intensive care patients participated.

The analysis shows that the mortality rate dropped from 59.5 percent at the end of March to 42 percent at the end of May – a relative decrease of almost a third.

Despite some differences in the criteria for admission and the treatments performed, the mortality rate in the intensive care unit did not differ significantly between the continents.

The UK coronavirus mortality rate has dropped to a quarter of the level it had at the height of the crisis

The risk of dying from coronavirus after a hospital stay has decreased since the peak of the outbreak, adding more fuel to the theory that doctors treat it better.

Oxford University analysis shows that 6 percent of the people who were brought to the hospital in England with the virus died in early April.

However, the numbers show that by June 15, only 1.5 percent of Covid-19 patients died from the disease – a quarter of the level at the height of the crisis.

Oxford statisticians can't say exactly why survival rates have dropped so much – but they believe doctors may be able to treat the virus better.

In April, there was no approved drug to treat Covid-19, a disease that was still puzzling after the jump from animals to humans in late 2019.

The NHS now has two drugs to treat critically ill patients – the Ebola drug Remdesivir and the anti-inflammatory steroid dexamethasone.

There are also probably fewer people who contract the coronavirus in the hospital than at the height of the crisis, which may have contributed to the decline in mortality rates.

Hospital patients are inherently uncomfortable or older and therefore die more often when they get it.

The researchers point out that at the time of the studies, there were no scientifically proven drugs to treat the disease.

The results suggest that doctors can better assess when patients need to be ventilated and how their symptoms can be alleviated with pain relievers and antibiotics.

Now doctors have two drugs in their arsenal to treat critically ill patients – the Ebola drug Remdesivir and the anti-inflammatory steroid dexamethasone.

Dexamethasone, a £ 5 steroid that has been around for decades, was the first drug that has been shown to lower mortality rates in hospital patients who need oxygen.

Evidence around remdesivir is inconsistent, but studies have shown that it helps the most seriously ill who need ventilation.

Lead author Tim Cook, an NHS consultant professor of anesthesia at the University of Bristol, said he expected the mortality rates to continue to improve thanks to the medication.

In the study, he wrote: “This systematic review and meta-analysis of the result in the intensive care unit in patients with COVID-19 showed an international mortality rate of 41.6 percent in the intensive care unit.

& # 39; There was no significant geographic impact, but reported intensive care mortality decreased over time.

"Optimistically, we can better deal with COVID-19 as the pandemic progresses."

According to an analysis by Oxford University, the mortality rates of patients hospitalized with the virus have dropped since the peak of the outbreak.

Six percent of the people hospitalized with the virus in England died in early April.

However, numbers show that by June 15, only 1.5 percent of Covid-19 patients died from the disease – a quarter of the level at the height of the crisis.

There are also probably fewer people who contract the coronavirus in the hospital than at the height of the crisis, which may have contributed to the decline in mortality rates.

Hospital patients are inherently uncomfortable or older and therefore die more often when they get it.

Of 10,387 people who were hospitalized in England with Covid-19 on April 2, 644 died, which corresponds to a mortality rate of 6 percent.

On June 15, 50 out of 3,270 hospitalized patients fell victim to the disease, which is around 1.5 percent.

While most scientists believe that the decrease in deaths is due to doctors gaining a better understanding of the treatment of the virus, some believe that Covid-19 has been weakened since it first appeared in Wuhan last December.

Oxford University analysis shows that 6 percent of the people who were brought to the hospital in England with the virus died in early April. However, the numbers show that by June 15, only 1.5 percent of Covid-19 patients had become victims of the disease - a quarter of the peak

Oxford University analysis shows that 6 percent of the people who were brought to the hospital in England with the virus died in early April. However, the numbers show that by June 15, only 1.5 percent of Covid-19 patients had become victims of the disease – a quarter of the peak

The top Italian doctor, Professor Matteo Bassetti, said he was convinced that the severity of the virus was changing and that patients were now surviving infections that had previously killed them.

And if the virus is weakened, Covid-19 could even go away without a vaccine by becoming so weak that it dies out on its own, he claimed.

In the past few months, he has said several times that patients with Covid-19 appear to be doing much better than when the epidemic started in Italy.

Professor Bassetti suggests that this could be due to a genetic mutation of the virus that makes it less deadly, improved treatments, or that people are not infected with such high doses due to social distance.

But other scientists have resorted to claims in the past, saying there is no scientific evidence that the virus has changed at all.

Professor Bassetti, the head of infectious diseases at the San Martino General Hospital in Genoa, Italy, told The Sunday Telegraph earlier this month that the virus could die on its own.

Professor Matteo Bassetti,

Professor Matteo Bassetti, chief of infectious diseases at the San Martino General Hospital in Genoa, Italy, said the virus has changed since March and April

He said, "It was like an aggressive tiger in March and April, but now it's like a wild cat. Even elderly patients aged 80 or 90 now sit in bed and breathe without help. The same patients would have died two or three days earlier. & # 39;

Italy was one of the most affected countries in the world at the beginning of the pandemic and has now recorded more than 238,000 positive cases and 34,000 deaths.

Scientists have said that the older population there, the spread of the virus in rural areas and the sudden onset of the outbreak have contributed to the high death toll in the country.

HOW AND WHY CAN VIRUSES LOSE POTENTIAL OVER TIME?

Viruses are known to change over time as they are subject to random genetic mutations in the same way as all living things.

These mutations can have various effects and many will only appear briefly and will not become a permanent change as newer generations of viruses replace the mutated ones.

However, some of the mutations could prove beneficial to the virus and spread to future generations.

For example, if a virus becomes less dangerous to its host, causing fewer symptoms or fewer deaths, it may find that it can live longer and reproduce more.

As a result, more of these less dangerous viruses are produced and may spread more effectively than the more dangerous versions that could be eliminated by medication, for example because more people recognize that they are sick.

The mutation can then be advanced in the stronger generations and become the dominant version of the virus.

In a statement from a scientific study on HIV in 2014, the NHS said: "The optimal evolution strategy for a virus is to be infectious (to make more copies of itself) but not to be fatal (so that the host population does not die out). .

"The" figurehead "for successful long-lived viruses is probably the family of viruses that cause the viruses that have existed for thousands of years."

Professor Bassetti suggests that one of the reasons why the virus could cause less serious diseases is a genetic mutation that has made it less harmful to people's lungs.

Or, he said, people may just get lower amounts if they get infected because of social distance and lockout rules that make them less sick.

This theory depends on the severity of a person's illness that is affected by their "viral load" – the amount of virus that enters a person's body when they are first affected.

Professor Bassetti said: “The clinical impression I have is that the severity of the virus changes.

& # 39; In March and early April, the patterns were completely different. People came to the emergency room with a very difficult disease to treat and needed oxygen and ventilation, some developed pneumonia.

& # 39; Now, in the past four weeks, the picture has changed completely in terms of patterns.

"There could be a lower viral load in the airways, probably due to a genetic mutation in the virus that has not been scientifically proven."

The infectious disease doctor has made similar claims in the past, but has raised criticism for being too optimistic.

In early June, he said, "The strength of the virus two months ago is not the strength it has today."

However, other scientists did not welcome the idea and said there was no evidence to support Professor Bassetti's claims.

Dr. Gideon Meyerowitz-Katz of the University of Wollongong in Australia told MailOnline that the idea that the virus had disappeared appeared "doubtful".

The epidemiologist warned Italy – which was at the center of the European coronavirus crisis in March – that new Covid 19 cases and deaths were still being recorded, showing that the virus is still a danger.

At the beginning of June, Dr. Angela Rasmussen of Columbia University in response to Professor Bassetti's claim: "There is no evidence that the virus is losing effectiveness anywhere."

She added that less transmission means fewer hospital stays and fewer deaths, but warned, "It doesn't mean less virulence."

The virulence of a virus is how dangerous the disease is, but may not be directly related to how contagious it is.

Dr. Seema Yasmin, an epidemiologist from Stanford University, said the idea was "bull ***".

Dr. Oscar MacLean of the University of Glasgow added: “These claims are not supported by anything in the scientific literature and appear to be rather implausible for genetic reasons as well.

"The vast majority of SARS-CoV-2 mutations are extremely rare. Although some infections can be mitigated by certain mutations, they are unlikely to be common enough to change the type of virus at a national or global level. " .

“Making these claims based on anecdotal observations from swab tests is dangerous.

“Although a weakening of the virus by mutations is theoretically possible, we shouldn't expect this, and claims of this kind should be checked more systematically.

"Without much stronger evidence, nobody should unnecessarily downplay the risk of this highly virulent virus and risk the sustained community-wide response."

(tagsToTranslate) Dailymail (t) messages (t) coronavirus