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Exercise PILL hopes after liver protein has worked in the mouse brain


You may not need the gym when it's finally open again! An "exercise pill" could be in sight after scientists found that raising the level of a liver protein mimicked the benefits of training in the brain of mice

  • The researchers examined the blood of older mice, which regularly trained compared to sedentary mice
  • They found elevated levels of a liver protein called Gpld1 and genetically modified older mice to overproduce it
  • Three weeks of treatment improved memory and learning, similar to six weeks of training
  • Glpd1 appears to work by reducing inflammation and blood clotting, both of which are risk factors for dementia
  • Scientists hope that one day this treatment could be available in pill form for adults who cannot be active

According to a new study, increasing liver protein levels could offer the brain the benefits of exercise.

In studies on mice, scientists found that high blood levels of a protein called Gpld1 corresponded to improved cognitive function in aging rodents.

In addition, the results suggest that the benefits of exercise for the brain may one day be available in pill form.

The team from the University of California at San Francisco, Eli, and the Edythe Broad Center for Regenerative Medicine and Stem Cell Research says that a pill or injection would be especially helpful for those who cannot exercise because of physical limitations so they can continue to be treated neurologically can accomplishments.

In a new study by USCF, the researchers found that three weeks of overproduction of liver protein improved memory and learning in mice, similar to six weeks of training (file image).

"If there were a drug that had the same brain benefits as exercise, everyone would take it," said lead author Dr. Saul Villeda, assistant professor at the departments of anatomy and physiotherapy and rehabilitation science, in a press release.

"Now our study suggests that at least some of these benefits might one day be available in pill form."

Exercise has long been known as one of the best ways to protect the brain from age-related diseases, but many older adults are unable to exercise restrictions or disabilities.

For decades, researchers have been looking for therapy or treatment for adults who cannot have the same neuroprotective effects as those who can.

For the study, which was published in the journal Science, the researchers took blood from aging mice, which regularly trained for seven weeks, and transferred it to older rodents that were sitting.

The results show that the less active mice showed improvements in learning and memory after four weeks and showed values ​​similar to those of the training mice.

The team found a higher production of neurons in the hippocampus, the part of the brain that is responsible for memories and learning ability.

In order to investigate which specific factor is behind the results, the researchers measured different proteins in the blood of the active mice compared to the sedentary mice.

Of 30 candidates, two are – Gpld1 and Pon1 – emerged and scientists decided to deal with the former because of a lack of research.

"We thought that if the protein had been thoroughly examined, someone would have come across this effect," said Villeda.

"I want to say – if you take a risk by discovering something new, you might as well make it big!"

The researchers genetically engineered the livers of old mice to overproduce Gpld1 and then tested them for learning and memory.

They found that three weeks of treatment gave beneficial results, similar to six weeks of training.

In addition, Gpld1 levels in the blood of older adults who are active increase compared to sedentary adults.

"To be honest, I didn't expect to find a single molecule that had so many advantages of movement in the brain," said Villeda.

“It seemed more likely that exercise would have many small, subtle effects that would be very useful but difficult to isolate. When I saw this data, I was completely done. & # 39;

The authors say that the protein does not work by crossing the blood-brain barrier, but by reducing inflammation and blood clotting, both of which are risk factors for dementia.

For future studies, the team plans to investigate how Gpld1 interacts with other blood factors to improve brain function.

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